SMARTLAB INTELLIGENT XRD FOR PHARMACEUTICALS


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MULTIPURPOSE X-RAY DIFFRACTION SYSTEM WITH BUILT-IN INTELLIGENT GUIDANCE

The complete solution for X-ray powder diffraction analysis of API, amorphous intermediates and final drug product material.

Unique functionality for pharmaceutical materials characterization:
✔️ In situ XRD – DSC analysis with optional controlled humidity
✔️ Easy to use transmission capillary spinner with optional non-ambient control
✔️ Automated Reflection / Transmission change over and alignment
✔️ Integrated cluster tool and direct derivation component analysis for standardless quantitative analysis.
✔️ Intelligent indexing for small molecule organics.

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TRUSTED APPLICATIONS

SOLVING YOUR MOST PRESSING PROBLEMS

  • XRD quantification of POLYMORPH IMPURITIES

  • Quantitation of TRACE IMPURITIES in API

  • CRYSTAL STRUCTURE ANALYSIS

  • API POLYMORPHIC FORMS characterization

  • VARIABLE HUMIDITY USING XRD-DSC

  • µ diffraction mapping and PHASE ANALYSIS of drug prodct

APPLICATIONS

CONFIDENCE WHEN YOU NEED IT MOST

  • Raw material identification (RMID) of pharmaceutical, nutraceutical and cosmetic ingredients

  • Verification of trial materials, chemical, solvents and cell culture media

  • Authentication of finished products and anti-counterfeit prevention

INDUSTRY-LEADING SUPPORT

OUR COMMITMENT TO CUSTOMERS

  • 24/7 PHONE SUPPORT
  • IQ/OQ/PQ PROGRAM
  • SOP DEVELOPMENT

MADE IN THE USA

FOCUSED CUSTOMER SUPPORT

CUTTING EDGE TECHNOLOGY

Built-in Intelligent Guidance X-ray Diffraction (XRD) Instrument

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SmartLab XE 

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SmartLab XE 9kW with in situ DSC and 2D detector

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SmartLab XE with ASC 48 transmission / reflection auto changer

FEATURES & BENEFITS

❗ Automated Multipurpose X-ray powder diffractometer.

❗ 21 CFR Part 11 compliant audit trail with electronic signature and records.

❗ Can be used for solid and bulk samples, powder, gels, creams, liquids, and tablets.

❗ Optimum data quality ensured through the choice of high power 9 kW PhotonMax source or conventional X-ray tube (3kW) combined with a 1D or 2D photon-counting detector.

❗ Routine and automated inter-change between transmission and reflection geometries for orthogonal characterization of organic powders and solid samples.

❗ Ideally suited for high sensitivity phase Identification and Quantitation coupled with the ability to perform advanced sample characterization.

❗ Advanced analysis options include Pair Distribution Function (PDF) analysis, Small Angle X-ray Scattering (SAXS), Micro diffraction, Indexing, organic molecular Structure Solution (Ab initio), and Refinement (Rietveld).

❗ Automated instrument alignment and optimization maintain the instrument performance within the acceptable validated range and ensure the reproducibility required for robust sameness testing and cluster analysis.

❗ Full range of in-situ non-ambient (temperature and humidity) stages available including Differential Scanning Calorimetry (DSC).

❗ A theta/theta Johansson Kα1 configuration is available for robust indexing and structure solution applications. The Kα1 monochromator can be rapidly interchanged with standard reflection/transmission optics.

❗ Standardless quantitative analysis of complex mixtures using the total diffraction direct derivation (DD) method.

❗ Non-destructive analysis allowing the correlation of diffraction data with subsequent product performance.

Multiple sample stages to suit application:

  • Heating and Cooling stages
  • Controlled humidity stages
  • In situ DSC (with humidity scanning)
  • Auto sample changers (6, 10, 48 position)
  • Sample spinners
  • Capillary stage with spinning
  • X, Y, Z mapping stage
  • Bulk sample holders
  • High throughput screening 96-well plate
  • Isolation cells (for reactive or toxic materials)
  • Disposable single-use holders

TRUSTED PARTNER

WHO WE ARE
Pharmaceuticals have the power to change the world for the better, but before they can ever do that, they need to be proven safe and trustworthy. Here at Rigaku, we strive to make this a reality as the leading global scientific analytical instrumentation company specializing in X-ray and thermal analysis, and Raman spectroscopy.

CORPORATE MISSION
To contribute to the enhancement of humanity through scientific and technological development.

CORPORATE MOTTO
Value our customers, value our people, and value our technology

 

HOW WE WORK WITH YOU

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