SMARTLAB INTELLIGENT XRD FOR PHARMACEUTICALS

The complete solution for X-ray powder diffraction analysis of API, amorphous intermediates and final drug product material.

CUTTING EDGE TECHNOLOGY

SmartLab XE 

SmartLab XE 9kW with in situ DSC and 2D detector

SmartLab XE with ASC 48 transmission / reflection auto changer

FEATURES & BENEFITS

❗ Automated Multipurpose X-ray powder diffractometer.

❗ 21 CFR Part 11 compliant audit trail with electronic signature and records.

❗ Can be used for solid and bulk samples, powder, gels, creams, liquids, and tablets.

❗ Optimum data quality ensured through the choice of high power 9 kW PhotonMax source or conventional X-ray tube (3kW) combined with a 1D or 2D photon-counting detector.

❗ Routine and automated inter-change between transmission and reflection geometries for orthogonal characterization of organic powders and solid samples.

❗ Ideally suited for high sensitivity phase Identification and Quantitation coupled with the ability to perform advanced sample characterization.

❗ Advanced analysis options include Pair Distribution Function (PDF) analysis, Small Angle X-ray Scattering (SAXS), Micro diffraction, Indexing, organic molecular Structure Solution (Ab initio), and Refinement (Rietveld).

❗ Automated instrument alignment and optimization maintain the instrument performance within the acceptable validated range and ensure the reproducibility required for robust sameness testing and cluster analysis.

❗ Full range of in-situ non-ambient (temperature and humidity) stages available including Differential Scanning Calorimetry (DSC).

❗ A theta/theta Johansson Kα1 configuration is available for robust indexing and structure solution applications. The Kα1 monochromator can be rapidly interchanged with standard reflection/transmission optics.

❗ Standardless quantitative analysis of complex mixtures using the total diffraction direct derivation (DD) method.

❗ Non-destructive analysis allowing the correlation of diffraction data with subsequent product performance.

Multiple sample stages to suit application:

• Heating and Cooling stages
• Controlled humidity stages
• In situ DSC (with humidity scanning)
• Auto sample changers (6, 10, 48 position)
• Sample spinners
• Capillary stage with spinning
• X, Y, Z mapping stage
• Bulk sample holders
• High throughput screening 96-well plate
• Isolation cells (for reactive or toxic materials)
• Disposable single-use holders