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      The Pharma Lab Show: The Powerful Benefits of Pairwise Distribution Function

      Simon Bates, Ph. D.

       

      Pairwise distribution function (PDF) can be a very useful tool for pharmaceutical professionals, especially when characterizing active pharmaceutical ingredients.

      Using total diffraction and PDF analysis you can confirm — and even solve — the molecular structure of new materials in non-crystalline states in addition to characterizing the local molecular order.

      In this episode, Simon Bates, VP of Science and Technology at Rigaku, shares why PDF and total diffraction combined together are so powerful in confirming molecular structures and why they are opening the door to new materials in pharmaceutics.

      We discuss:

      • - The uses for PDF
      • - The challenges of total diffraction and PDF
      • - Keeping track of advances in PDF approaches

      Check out these resources we mentioned during the podcast:

      Learn more about Atomic Pair Distribution Function from Simon Bates here.
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      Check out the Rigaku Pharmaceutical Technologies Showcase for more information on Rigaku's commitment to the pharmaceutical industry
      Simon Bates, Ph. D.
      Simon Bates serves customers as the VP of Science and Technology with Rigaku Americas. Simon Bates received his PhD in Applied Physics from the University of Hull, utilizing Neutron diffraction to study the magnetic properties of rare earth materials. The neutron diffraction work was performed at the Institute Laue Langevin in Grenoble. For his postdoctoral work in the Dept. of Physics at the University of Edinburgh, Simon helped design and build high-resolution triple axis X-ray diffraction systems for the study of solid-state phase transformations. Simon continued his work on high resolution X-ray diffraction systems at both Philips NV and Bede Scientific where he was focused on the development of X-ray diffraction and X-ray reflectivity methods for the measurement and modeling of advanced materials. Before moving to Rigaku, Simon spent the last 15 years working in contract research organizations (SSCI and Triclinic Labs) studying solid state pharmaceutical materials. In particular, he was directly involved in the development of advanced characterization methods for formulated pharmaceutical products based on the analysis of structure (crystalline, non-crystalline, meso-phase, polymorph, salt, co-crystal..), microstructure (texture, strain, crystal size, habit..) and their functional relationships in the solid state. Simon also holds an appointment as an Adjunct Professor at LIU in the Division of Pharmaceutical Sciences where he helps teach a graduate course on solid state materials analysis.