The Pharma Lab Show: 'No Standards' Quantitative Analysis Using Chemometric Methods 

     

    For methods where standard mixtures are challenging to make and where you do not have virtual references, Chemometric approaches to quantitative analysis might be the answer. 

    In this episode of The Pharma Lab Show Live, we discussed:

    • How to apply Chemometric methods to X-ray powder diffraction data 

    • How to extract real reference components ‘standards’ from unknown mixtures (production batches). 

    • How to develop a Chemometric Quantitative program for crystalline content in Amorphous API. 

     

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    Learn more about The Application of Chemometric and Statistical Analysis Techniques for X-ray Diffraction Data

    Connect with Simon on LinkedIn or email to receive copies of the data files shown this week. 

     

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    Simon Bates, Ph. D.
    Simon Bates serves customers as the VP of Science and Technology with Rigaku Americas. Simon Bates received his PhD in Applied Physics from the University of Hull, utilizing Neutron diffraction to study the magnetic properties of rare earth materials. The neutron diffraction work was performed at the Institute Laue Langevin in Grenoble. For his postdoctoral work in the Dept. of Physics at the University of Edinburgh, Simon helped design and build high-resolution triple axis X-ray diffraction systems for the study of solid-state phase transformations. Simon continued his work on high resolution X-ray diffraction systems at both Philips NV and Bede Scientific where he was focused on the development of X-ray diffraction and X-ray reflectivity methods for the measurement and modeling of advanced materials. Before moving to Rigaku, Simon spent the last 15 years working in contract research organizations (SSCI and Triclinic Labs) studying solid state pharmaceutical materials. In particular, he was directly involved in the development of advanced characterization methods for formulated pharmaceutical products based on the analysis of structure (crystalline, non-crystalline, meso-phase, polymorph, salt, co-crystal..), microstructure (texture, strain, crystal size, habit..) and their functional relationships in the solid state. Simon also holds an appointment as an Adjunct Professor at LIU in the Division of Pharmaceutical Sciences where he helps teach a graduate course on solid state materials analysis.